a Based on the pedigree what is the most likely mode of inhe

a) Based on the pedigree, what is the most likely mode of inheritance for the disease?

b) Give the most likely genotypes of Arlene, Tom and Michael.

c) Sandra divorces Tom and marries Sam. Predict what proportion of their children will have the condition.

Sandra Daniel George Sam. Tom Christopher Arlene Wilma Ann Michael Carla

Answer:

a) It is an autosomal recessive mutation.

b).

A= dominant allele, normal

a= recessive allele, diseased

George= Aa

Arlene= aa

Tom= aa

Sam= Aa

Wilma= aa

Ann= Aa

Sandra= AA

Michael= Aa

Daniel= Aa

Alan= Aa

Tina= AA

Christopher= AA or Aa

c). Sandra genotype is AA (homozygous normal). If Sandra marries Sam (genotype, Aa), no progeny would be diseased.

AA (Sandra) X Aa (Sam)

AA, Aa (normal)---progeny