Below is a list of the first 10 residues of the B helix in m

Below is a list of the first 10 residues of the B helix in myoglobin from different organisms.

Which positions can tolerate conservative substitution?

Hint: Which positions are mostly the same, with only an occasional substitution?

I tried position 1&8 but it was wrong

Position 78910 Human DIPGHGOEVL Chicken DIAGHGHEVL Alligator Turtle DLSAHGOEVI luna DYTTMGGLVL DFEGTGGEVL ILL-ILL 8EEEELE 7QHHQGG 4GGEATG 3PAPSTE 21-LLYF 1DDKDDD

Solution

According to me answer will be 9 & 10.. As 9 is valine and 10 is isoleucine so both are non-polar in nature. If both of them are interchanged it will result in the conservative substitution.