Response optimization is used to determine the optimal condi
Response optimization is used to determine the optimal conditions for recovery of a sample for HPLC. The three factors are: A- Solvent (Hexane or Ethyl Acetate); B- pH (8 or 10); and C- time (30 or 60 minutes). The two response variables are Recovery and Variance. What are the optimal conditions for this process?
Run
Recovery
Variance
(1)
65.3
4.5
a
81.3
4.8
b
53.3
3.7
ab
69.9
5.5
c
61.8
3.7
ac
77.45
6.9
bc
73.9
3.6
abc
89.9
6.2
| Run | Recovery | Variance |
| (1) | 65.3 | 4.5 |
| a | 81.3 | 4.8 |
| b | 53.3 | 3.7 |
| ab | 69.9 | 5.5 |
| c | 61.8 | 3.7 |
| ac | 77.45 | 6.9 |
| bc | 73.9 | 3.6 |
| abc | 89.9 | 6.2 |
Solution
What are the optimal conditions for this process?
recovery of 65.3 and variance 4.5

