Using the diagram below and comparing to the dashed line sig

Using the diagram below, and comparing to the dashed line signaling no inhibitor was present, determine all possible reactions (of A, B, C, D, E) that contained a competitive inhibitor. Explain your reasoning in both quantitative AND qualitative terms (essential). Repeat for those containing noncompetitive inhibitor and again for uncompetitve inhibitor.

Explain your reasoning in quantitative and qualitative terms (this i containing noncompetitive inhibitor and again for uncompetitive i A B C No [I] I/IS]

Solution

C is the competitive inhibitor

Competitive inhibitors increase Km by interfering with the binding of the substrate, but they do not affect Vmax

D and E are the Uncompetitive inhibitors: these inhibitors decrease Km and decrease Vmax

A and B are the Non-competitive inhibitors: They do not change Km, but decreases Vmax.