Folic acid deficiencies lead to serious health issues as it

Folic acid deficiencies lead to serious health issues as it can lead to anemia and also to an increased amount of uracil incorporation into DNA. Speculate why these two very different outcomes may result from this deficiency. Provide pathway information

Solution

Folic acid also called as folate - a type of B vitamin , which is helpful in making of RNA, DNA and RBCs. It\'s deficiency include serious health related problem like anaemia in which there is a very less count of RBCs. Deficiency of folic acid occur by two ways either your dietary supplement is very less or majorly you have genetic disorder, in some few disorder also responsible for the occurrence of this condition.

Why anaemia?

Folic acid is used in body in two forms, one is methylcobalamin and second one is 5 deoxyadenosyl cobalamin. 5 deoxyadenosyl cobalamin is a cofactor used by enzyme for the conversion of l methylmalonyl CoA to succinyl CoA. Succinyl CoA is responsible for the production of haemoglobin, hence in absence of folic acid , succinyl CoA is not formed.

Folic acid deficiency responsible for the increase level of dUMP in cell which leads to excessive uracil incorporation in DNA.