Which of the following statements about genomewide associati

Which of the following statements about genome-wide association studies are true?

a) Genome-wide association studies based on the trio design would be least appropriate when severe population structure is apparent.

b) In Drosophilia, there is almost no linkage disequilibrirum (even between adjacent SNPs). Therefore, a strong association in Drosophilia for a given SNP likely indicates thast the SNP is causal (functional) SNP for the phenotype being studied

c) in performing genome-wide association studies in Arabidopsis, fewer tag SNPs would be needed in centrometric regions (that is, the DNA in and around centromeres)

d) in genome-wide association studies, detection of rare alleles as causal for trait variation is typically only possible if the rare alleles have a very large impact on phenotypes

e) in a genome-wide association study, taking the negative log of the P-value is a required step to assess statistical significance.

Solution

c) in performing genome-wide association studies in Arabidopsis, fewer tag SNPs would be needed in centrometric regions (that is, the DNA in and around centromeres)

Single nucleotide polymorphisms are the most common type of genetic variation in humans. One SNP represents a difference in a single DNA building block which is a nucleotide. They can be genetic makers to genes that can potentially develop into diseases or cancers. It can also help predict someone\'s response to a certain drug, susceptibility to environmental factors like toxins, and the risk of getting certain diseases. They look for SNP\'s that appear more frequently in people who have certain diseases so to better identify people who might develop a certain kind of disease or is more susceptible to develop a disease.