11 The human immunodeficiency virus HIV is a retrovirus that

11. The human immunodeficiency virus (HIV) is a retrovirus that infects immune cells. Which of the

following aspects of HIV biology would NOT be a theoretically useful target or strategy for

elimination of viral spread?

a. the tat protein that interferes with transcription termination in the host cell

b. inhibition of RNA polymerase II CTD phosphorylation

c. the enzymes required for viral reverse transcription

d. chromatin status of the region of viral integration in the host genome

Solution

b. Inhibition of RNA polymerase II CTD phosphorylation.

This enzyme is not needed for HIV virus life cycle Viral RNA uses reversse transcriptase to make complementry DNA. so targeting RNA polymerase II CTD phosphorylation will not help.