Does native Con A exist as a monomer dimer trimer or tetrame

Solution

At pH=5, the Concanavalin exists as dimer. At pH= 5, Con A exists as three dimeric types are possible: Homologous dimers of either 2 intact or 2 fragmented monomer units and a hybrid dimer consisting of one monomer of each form. Binding results indicate:

a. That a mixture of dimeric types must bind at pH=5, some types having one binding sites per molecule;

b. That species must have similar affinity for ligand.