0 2 pts Incorrect Question 6 Select ALL the TRUE statements

0 2 pts Incorrect Question 6 Select ALL the TRUE statements regarding PDH complex. Thiamine deficiency causes Beriberi due to inadequate PDH activity in the brain. Cytosolic PDH has a higher Km than the mitochondrial PDH, since you want most pyruvate in the mitochondria. PDH is found on the mitochondrial membrane. It is encoded by a single gene.

Solution

Q 6. PDH is not found on the mitochondrial membrane. It is found in the matrix of mitochondria.The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). These different components are encoded by different genes. Hence the statements third and fourth are not true. The statement first and second are true.

Q 6. Here the answer will be oxaloacetate. TCA cycle proper starts with the condensation of acetyl CoA and oxaloacetate. The step in which formation of acetyl CoA from pyruvate takes place, is the connecting link between glycolysis and TCA cycle. Hence acetyl CoA will not be considered the internmediate of TCA cycle.

Q 5. Here the answer will be H₂O₂. The most common reactive oxygen species include ¹O₂, O₂^•, H₂O₂, and •OH and from these common reactive oxygen species, only H₂O₂ is there in option.

Q 11. Here the answer will be 0. (Since the reaction is: FADH₂ + 1/2 O₂ = FAD + H₂O). Hence there will be no charge on FAD.