Questions l Gerhart and Pardee measured ATCase activity in t

Questions l. Gerhart and Pardee measured ATCase activity in the presence of a variety of purine and pyrimidine derivatives. Their results are presented in Table 16.2. What compound (s) were the most effective inhibitors? activators? Explain the significance ofthe metabolites that served as inhibitors or activators in the context of the biosynthetic pathway presented in Figure 16.1. Table 16.2: Effect of nitrogen bases, nucleosides and nucleotides on ATCase activity. \"Indicates stimulation. (Based on Gerhart and Pardee, 1962.) Compound Inhibition, (Conc 2 mM) Cytosine Cytidine 24 CMP 38 dCMP 48 CTP dCTP 88 UTP GTP 35 dGTP ATP 180 dATP -162

Solution

ATCase activity was measured in the presence of a variety of purine and pyrimidine derivatives. Their results are presented in table below. What compound(s) were the most effective inhibitors? activators?

B. (10 pts) Explain the significance of the metabolites that served as inhibitors or activators in the context of the biosynthetic pathway presented in Figure 1.