A paired samples t test is appropriate when there are two me

A paired samples t test is appropriate when there are two measurements per person in one independent sample. An independent samples t test is appropriate when there is one measurement per person in two independent samples.

Can you think of a way to combine these two tests into a single design? In other words, is there a method that allows one to test the difference in means between two groups when the dependent variable is the difference between two measurements?

Solution

In my view cox regression which is used for survival analysis can be useful in the given circumstances.