Two parents who do not have sickle cell anemia have a child

Two parents who do not have sickle cell anemia have a child that has the disease. The parents are both:

1.) Pleiotropic for the sickle cell allele

2.) Homozygous for the sickle cell allele

3.) Homozygous for the normal allele

4.) Heterozygous for the sickle cell allele

5.) Epistatic for the sickle cell allele

Solution

Answer:

Sickle-cell disease is caused by a gene mutation that leads to the production ofSickle haemoglobin, which affects the function of the red blood cells in the body. This mutation is inherited from the parents of an individual in an autosomal recessive pattern.

S= normal allele (dominant)

s = Sickle cell allele (recessive)

Ss X Ss ----------Parents (both are normal)

S

s

S

SS (normal)

Ss (normal)

s

Ss (normal)

ss (sickle cell anemia)