the body 4 hr how much drug would be remain ra patient takes

the body 4 hr, how much drug would be remain ra patient takes a 100 mg dose a drug A (with halflifeof4hr) wery (b) If this patient follows the above schedule but forgot to take a dose at hr 12, then take a double-dose at hr 16, what is the amount of drug remaining in the body at hr 24 halflives laterg ng (e) If this patient forgot to take a dose at time hr 12 tas in (b), but followed the doctor\'s instruction to take a regular dose afterwards instead of double-dose, what is the amount of dru body at hr 2406 half lives later (d) For antibiotics (with half life of4 hr), doctor asks the patient to take a double-dose initially at hr 0, then a regular-dose every n the body at 24 hr and 48 hr? 4-hr, what is the amount of dr 100 mg 100 mg total drug (Bonus) Compare the drug left in the body at 24 hr for the above scenarios (a) -(e)

Solution

e) At 0 hours,

Dose administered=100mg

Total drug accumulated= 100mg

At 8 hours

Dose administered= 100mg

Total drug accumulated= 100\\2+100=150mg

At 16hours

Dose administered=100mg

Total drug accumulated= 150\\2+100=175mg

**At 24 hours

Dose admisistered=100mg

Total drug accumulated=175\\2+100=187.5mg

At 32 hours

Dose administered=100mg

Total drug accumulated=187.5\\2+100=193.75mg

At 40 hours

Dose administered=100mg

Total drug accumulated=193.75/2+100=196.9mg

**At 48hours

Dose administered=100mg

Total drug accumulated=196.9\\2+100=198.4mg

a)When the patient takes a regular dose of 100mg every 4 hours he is left with 198.4mg of drug at the end of 24 hours.

b)when the patient forgets a dose at 12 hours and takes a double dose at 16 hours he will be left with more drug in his system than at regular dosage. 211mg

c)when the patient forgets dose at 12 hours and does not take a double dose he has lesser drug in his system. 186mg

d)if the patient takes takes a double dose at 0 hours and then continues with single dose retains the double dose in his body. 200mg

e)with a half life of 8 hours the patient retains 187.5 mg at 24 hours and 198.4mg at 48hours.