att Pyruvate runon 11 4 pts 23Bisphosphoglycerate is an allo

att Pyruvate runon 11. (4 pts) 2,3-Bisphosphoglycerate is an allosteric regulator of hemoglobin and is required to keep the enzyme phosphoglycerate mutase active. The 2,3-BPG shunt shown below. C- O C O OT 1,3-BPG mutase 2,3-BPG phosphatase HC-OH HC-OH HC-O H2C-O- P-O H2C-O-P-O H2C-O- P -O If all of the glucose were metabolized through this 2,3-BPG shunt into lactate, what would be the net reaction for the conversion of glucose to lactate?

Solution

The 2,3 BPG shunt is said to be the product involved the Luebering-Rapoport pathway (The Rapoport-Luebering glycolytic shunt).

This pathway or shunt involves the formation of 2,3 BPG.

This 2,3 BPG regulates oxygen release from the hemoglobin and delivery to tissues.

During the standard glycolysis pathway 1,3-BPG is converted to 3-PG in a single step, generating an ATP molecule, and by directing 1,3-BPG to the Rapoport-Luebering shunt the cell gives up the production of this ATP molecule. However, the purpose of this shunt is the production of 2,3-BPG, which is a key regulator in the cell.

First, the 2,3-BPG produced plays an essential role in the glycolysis.

Secondly, 2,3-BPG produced acts as a key regulator of oxygen release from erythrocytes by binding to the deoxyhemoglobin.