Using 10 amino acids as building blocks propose a sequence f

Using 10 amino acids as building blocks, propose a sequence for an integral protein. Your sequence must have a transmembrane portion of a length of 6 amino acids, and you must have at least 2 amino acids inside and 2 outside the cell. Draw and label your polypeptide with respect to the plasma membrane

Solution

Since intergral poteins are present in lipid bilayer the hydrophobic amino acids Phe, Leu, IIe and Val will have high preference. Other amino acids could be Ala, Met, Pro, His, Gly and Cys.

The trans membrane portion of a 6 amino acid length will be Phe, Leu, IIe, Val, Ala and Met. The amino acid inside of the cell will be Ala, Gly and the amino acids towards extracellular region will be Lys, Asp.