What is an example of how lineage and enviornment affect dif

What is an example of how lineage and enviornment affect differentiation of a cell.

Solution

Cellular differentiation is a process where cell change from one cell type to another most importantly into a specialized cell type. Physical property of tissue and environment directly regulate the cell fate and example of this is an environment with high stiffness drives stem cells (MSCs) to undergo osteogenic differentiation which is induced by increasing collagen content extracellularly , the actin content intracellularly this is done with the change in the gene expression profile which ultimately decide the fate of the cell