To what extent do peroxisomal matrix protein import and pero

To what extent do peroxisomal matrix protein import and peroxisomal membrane protein import share the same machinery?

Solution

Answer: Peroxisomal matrix protein import and peroxisomal membrane protein import are going to share the same machinery only to a certain extent & majority of pathways are different when importing proteins from endoplasmic reticulum to \"peroxisome matrix\" & \"peroxisome membrane\". The targeting proteins to peroxisome are mainly mediated by peroxisomal-targeting sequence-1 (PTS1) & peroxisomal-targeting sequence-1 (PTS2) in both peroxisomal matrix protein import and peroxisomal membrane protein import. This sequence has ser-lys-leu or a amino acid residues at the C-terminus. Initially, PTS1-bearing proteins (for example, catalase) is imported to peroxisomal matrix via soluble carrier proteins known as \"Pex5\". This process is mediated via ubiquination and deubiquniation. The other proteins have also involved in this transport are Pex10, Pex12 and Pex2 & the import process in both \"matrix\" & \"membrane\" of peroxisomes are ATP dependent.