Hemoglobin can assist with blood buffering Which of the foll

Hemoglobin can assist with blood buffering. Which of the following does not contribute to buffering through hemoglobin and the Bohr Effect?

a. The action of carbonic anhydrase

b. H+ binding to various His residues

c. Formation of biocarbonate from carbon dioxide

d. Heme decreases affinity for oxygen as both carbon dioxide and concentrations of H+ increase

e. Binding H+ on carbamino-terminal residues of hemoglobin

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Solution

Carbonic acid and bicarbonate system is most effective buffering system, because the bicarbe level in plasma is equilibrium with the dissolved Carbon dioxide.this is mainly mediated by carbonic anhydrase activity. Heamoglobin has 38 histidine molecule. H+ binding to it also act as buffer. Formation of bicarbonate from Carbon dioxide, is also a buffer system. C and N terminal ends of the plasma proteins, binding with acid and alakli act as buffer system.it amphoteric in nature. Beheave as acid or base depending on the situation. Option D. Is wrong. Since oxigen binding capacity does not act as buffer system.