Which of the following will likely result in a misfolded pro

Which of the following will likely result in a misfolded protein (mark ALL that apply)?

a. Mutation in promoter

b. Mutation in DNA sequence

c. Mutation in splice site

d. Mutation resulting in aberrant STOP codon

Solution

b. Mutation in DNA sequence

c. Mutation in splice site

d. Mutation resulting in aberrant STOP codon

All the above options will apply

Promoter is the region of DNA, from where the transcription initiation will start. So, any muation in promoter, will not allow the transcription to initiate.

Any change (either addition or deletion of bases) in a gene will result in the alteration of amino acid sequence of the protein, will result in misfolding of the protein.

When there is a deletion of a splice site, the mature mRNA will have one or more introns, which will lead to the production of protein with different amino acid composition, thus there is a chance for protein to misfold.

The information needed for the folding of the protein will lie in its amino acid sequence, due to mutation in aberrant stop codon, if protein produced will be either short or long in comparison to the original amino acid sequence, then the protein cannot fold into proper form, and polypeptide errors will lead to protein misfolding.