Which of the following is true about protein structure It is

Which of the following is true about protein structure? It is entirely determined by the DNA. Multiple tridimensional structures have the same function as long as the amino acid sequence is correct The different levels of problem structure are untested to each other. In order to achieve the proper structure, proteins require multiple levels of folding. Protein structure has no effect on the function of a protein.

Solution

Multiple tridimensional structures have the same function as long as the amino acid sequence is correct.

The third level of structure found in proteins, tertiary structure, refers to the spatial arrangement of amino acids that are far apart in the linear sequence as well as those residues that are adjacent. Again, it is the sequence of amino acid that specifies this final three dimensional structure. In water soluble globular proteins such as myoglobin, the main driving force behind the folding of the polypeptide chain is the energetic requirement to bury the nonpolar amino acids in the hydrophobic interior away from the surrounding aqueous hydrophilic medium. The polypeptide chain folds spontaneously so that the majority of its hydrophobic side chains are buried in the interior, and the majority of its polar, charge side chains are on the surface. Once folded, the three dimensional biologically active conformation of the protein is maintained not only by hydrophobic interactions, but also by electrostatic forces, hydrogen bonding and, if present, the covalent disulphide bonds. The electrostatic forces include the salt bridges between oppositely charged groups and the multiple weak van der Waals interactions between the tightly packed aliphatic side chains in the interior of the protein.