5Define heterophile antibody 6Describe role of RBCs from var

5.Define heterophile antibody.

6.Describe role of RBCs from various species (sheep, beef, ox, horse) in differentiating various classes of heterophile antibodies.

7.Which antibody is more specific for infectious mono: (heterophile ab or EBV ab) and explain why it is thought to be so.

8.What are some minor complications which may occur if condition is misdiagnosed or goes undiagnosed not treated properly? (see links)

9.What are some major complications which may occur if condition is misdiagnosed or goes undiagnosed not treated properly? (see links)

10. How does the treatment differ for strep vs mono?

11.If monotest is negative and Dr. still suspects infectious mono, what test

   will Dr. most likely order?

12.In adults with infectious mono, how likely is it to test positive for mono

   i.e. what is monotest sensitivity?

13.Tammy has more lymphs than segs in her diff. Is this diff distribution

    normal for an adult?

14.What types of infection cause an increase in lymphs above the normal
  range?

Resources links:

Infectious Mono

http://labtestsonline.org/understanding/analytes/mono/tab/test

http://www.healthline.com/health/mononucleosis

Solution

5. we dianoses the presence of heterophile antibody in infectious mononucleosis disease.

these antibodies are produced against poorly defined antigens. basically they are produced by weak antigen which are having multispecific activity.

6. heterophile antibody show great reactivity with other animal antibody called HUMAN ANTI ANIMAL ANTIBODY in the immunoessay. various animal RBC contain antibody on its surface that react with heterophile antibody and agglutinate. it is a useful mechanism for differentiating various heterophile antibody. example- antisheep heterophile antibody.

7. Heterophile antibody is more specific in infectious mononucleosis. Latex agglutination test is used for diagnosis horse RBC is agglutinated by heterophile antibody. this test show 100% specificity.

8. the leading cause of misdiagnosis or undiagnosis is if patient suffering from strep throat as the symptoms are quite similar with mononucleosis.

the heterophile antibody test may be negetive in early stage, it is positive 4-6 weeks after the onset of disease.