Which of the following is NOT true of tumor suppressor genes

Which of the following is NOT true of tumor suppressor genes? They are negative regulators of cell division. Loss of function mutations in tumor suppressor genes can lead to increased rates of cell division and cancer. They are oncogenes. Cancer causing alleles of tumor suppressor genes are generally recessive. All of the above are true of tumor suppressor genes.

Solution

Answer: They are oncogenes

1-Tumor supressor genes are the genes that protect cells from going to the cacerous path. When this gene mutates to cause a loss or reduction in function, the cell can leads to cancer.

2-Whereas the oncogenes are the cancer causing genes. They are often mutated to gain in function and expressed at higher levels in a cancerous cells.

3-The loss of the tumor supressor genes may be even more important than proto-oncogene/oncogene activation for the formation of many kinds of human cancer cells. So the loss of function in tumor supressor genes can lead to increased rate of cell division and cancer

4- Unlike oncogenes, tumor suppressor genes generally follow the \"two-hit hypothesis,\" which implies that both alleles that code for a particular protein must be affected before an effect is manifested. This is because if only one allele for the gene is damaged, the second can still produce the correct protein. In other words, mutant tumor suppressors\' alleles are usually recessive whereas mutant oncogene alleles are typically dominant.