Here is a family pedigree for an imprinting disorder caused

Here is a family pedigree for an imprinting disorder caused by a loss of function mutation in a gene. After generation related individuals are single imprinted shown. that the parents not included in the pedigree did not You can assume carry the mutation. OITO Male O Female Affected carrier a) Does the mutation involve a gene that is normally expressed from the maternal or from the paternal allele? Briefly explain your logic. (3pts) b) Identify two ways in which the pattern of inheritance shown in the pedigree is different from X-linked inheritance (3pts) Parthenogenesis has been documented in most vertebrate Classes (e.g. birds, never in imprinting provides one explanation for this observation. Why? (3pts) ll.

Solution

The paternal imprinting is nothing but the allele is imprinted from the father. The maternal imprinting is allele is imprinted from the mother.

General rule to solve the imprinting problem are,

1. For parental imprinting
1.1 Half the progency of affected female will be affected regardless of their gender.
1.2 Half the progency of carrier female will be affected regardless of their gender.
1.3 Half the progency of carrier male will be carrier regardless of their gender.

2. For maternal imprinting
2.1 Half the progency of affected male will be affected
regardless of their gender.
2.2 Half the progency of carrier male will be affected regardless of their gender.
2.3 Half the progency of carrier female will be carrier regardless of their gender.

The mutation happen in the imprinted gene of parental allele of the father it turns in to loss of function of that gene. So, it leads to parental imprinting.

B. In X-linked inheritance the rule to solve the pedigree problems are,
1. X-linked Dominant
1.1 Affected males produce all affected female and no affected male offspring.

But here affected male is only carrier of offsprings.

2. X-linked Recessive
2.1 Compare to females more males are affected.

But here equal number of both male and females are affected and carrier.