In humans PKU phenylketonuria is a disease caused by an enzy

In humans, PKU (phenylketonuria) is a disease caused by an enzyme inefficiency at step A in the following simplified reaction sequence, and AKU (alkaptonuria) is due to an enzyme inefficiency in one of the steps summarized as step B here:

phenylalanine----A---> tysoine ----B---> CO2+H2O

a) A person with PKU marries a person with AKU. What phenotypes do you expect for their children? the answer is all normal

b) If one of the children from the mating described in part \"a\" were to marry a child from another family with the identical pedigree, what would be the probablity that their children would have

PKU? PKU or AKU?

AKU?

Note: assume that the mutation that causes PKU is epistatic to the mutation that causes AKU.

Solution

Exolanation:- Phenylketonuria is an autosomal recessive disease meaning that both alleles must be in mutated forn for the disease to develop. Since all individuals are in heterozygous condition thus the all children would be normal.

B. Half of the children would be suffering from phenylketonuria and half woyld be normal.