Glycolysis and gluconeogenesis are concurrent and complement

Glycolysis and gluconeogenesis are concurrent and complementary metabolic pathways. Which of the following is NOT TRUE? all enzymes and intermediates used in glycolysis and gluconeogenesis are a) the same, however run in opposite directions: from glucose to pyruvate and from pyruvate to glucose, respectively glycolysis catabolizes glucose to pyruvate and acetyl-CoA and 1 gluconeogenesis anabolizes acetyl-CoA and pyruvate to glucose. glycolysis and gluconeogenesis regulate the availability of glucose in the cell. the conversion of pyruvate m to phosphoenolpyruvate (fast step) and conversion of 16P m to fructose 6P (final step) m gluconeogenesis uses pathway specific enzymes which are not shared with glycolysis.

Solution

In glycolysis, the glucose is metabolized to pyruvate and acetyl-CoA. In gluconeogenesis, however the pyruvate is used to make glucose again and there is no role of acetyl-CoA,

therefore the correct option is the second one :

glycolysis catbolizes glucose to pyruvate and acetyl-CoA and gluconeogenesis anabolizes acetyl-CoA and pyruvate to glucose.