Can be more than one answer Platypus Venom Platypus venom ca

Can be more than one answer.

Platypus Venom Platypus venom causes excruciating pain. Which of the following drug actions could increase the sensation of pain when applied locally to pain sensing neurons? Inhibit opening of Ca^2+ gated channels located at axon terminal of pre-synaptic neurons Inhibit closing of K^+ gated channels located along axons Increase the number of neurotransmitter (ligand-gated) receptors located on post-synaptic neurons Competitive inhibition of ligand-gated receptors located on post-synaptic neurons Inhibit opening of Na^+ gated channels located along axons Decrease the rate of neurotransmitter reuptake by pre-synaptic axon terminal

Solution

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Reason:Nociceptin receptors located on post synaptic neurons are activated during hyperalgesia (i.e increased pain.)These receptors upon ligand binding stimulate and increase the release of neurotransmitter i.e.glutamate at the post synaptic axon terminal but decrease the rate of neurotransmitter reuptake by pre synaptic axon terminal.