Genomewide association studies rely on the principle that ma

Genome-wide association studies rely on the principle that markers that are closer on the chromosome to a causal variant will tend to show stronger statistical associations with the corresponding phenotype. Briefly explain why the physical proximity of the marker has this effect.

Solution

GENOME WIDE ASSOCIATION STUDIES:It is also known as whole genome association study.it is the study of genetic variation across the entire human genome.it is designed to identify genetic associations with observable taits or the presence or absence of a disease or condition.

in GWAS SNP are widely used as markers in genomes.theycausing amino acid changes, changes to mRNA transcript stability, and changes to transcription factor binding affinity . SNPs are by far the most abundant form of genetic variation in the human genome.

One genetic marker on chromosome 26 within the SEZ6L gene was significantly associated with time spent close to, and in physical contact with, the human. Two suggestive markers on chromosome 26, located within the ARVCF gene, were also associated with human contact seeking. Strikingly, four additional genes present in the same linkage blocks affect social abilities in humans...

The causal relationship between genetic polymorphism within a species and the phenotypic differences observed between individuals is of fundamental biological interest. The ability to predict genetic risk factors for human disease and agronomically important traits like growth rate and yield in plants require an understanding of both the specific loci that underlie a phenotype, and the genetic architecture of a trait. This relationship between phenotype and genotype has been of major interest at least since Mendel postulated the existence of ‘internal factors’ that are passed on to the next generation...