sh domains on proteins have functions please name the functi

sh domains on proteins have functions please name the functions of the following domains

Sh1

Sh2

Sh3

Solution

The function of SH2 domains is to specifically recognise the phosphorylated state of tyrosine residues, thereby allowing SH2 domain-containing proteins to localise to tyrosine-phosphorylated sites.

SH3 domain arbitrates intracellular protein-protein interactions through the recognition of proline-rich sequence motifs on cellular proteins.

The protein kinase domain or SH1 domain is a structurally conserved protein domain containing the catalytic function of protein kinases. Protein kinases are a group of enzymes that move a phosphate group onto proteins, in a process called phosphorylation.