In a patient with a rare immunodeficiency disorder genome an

In a patient with a rare immunodeficiency disorder genome analysis showed that one allele (one of the Iwo copies of a gene that codes for a protein) of a particular receptor was mutated. Although the patient still had one intact allele of the receptor, signaling mediated by the receptor was inhibited? What does it suggest about the mode of functioning of the receptor? The receptor acts as an enzyme The receptor binds to a G-protein The receptor functions as a dimer It is a nuclear receptor Micronutrients in diet are essential for various cellular function. Which divalent cation is essential in diet for the proper functioning of many signaling pathways? Answer the following questions briefly. (In one or two sentences) X, Y and Z are three components of a regulatory system. Both X and Y are transcription activators. How might X, Y and Z interact so as to form a sign sensitive delay element? Show graphically how such a sign sensitive delay element will effect gene expression

Solution

7. Ans B the receptor binds to g protein

These proteins are activated by G protein coupled receptors GPCRs that span the cell membrane. So the signalling molecules bind to a domain of gpcr located outside the cell whichin turn activates particular G protein.

hence the signalling gets inhibited and the response is not generated hence causing a rare immune deficiency disorder.