how will filtrate proteins affect the osmotic gradient betwe

how will filtrate proteins affect the osmotic gradient between the Glomerulus and the filtrate and what will happen to his GFR?

Solution

Osmotic pressure is the force exerted by proteins and works against filtration because the proteins draw water in. Increased osmotic pressure in the glomerulus is due to increased serum albumin in the bloodstream and decreases GFR, and vice versa. Under normal conditions, albumins cannot be filtered into the Bowman\'s capsule, so the osmotic pressure in the Bowman\'s space is generally not present, and is removed from the GFR equation. In certain kidney diseases, the basement membrane may be damaged (becoming leaky to proteins), which results in decreased GFR due to the increased Bowman\'s capsule osmotic pressure.(The filtration constant is based on the surface area of the glomerular capillaries, and the hydrostatic pressure is a pushing force exerted from the flow of a fluid itself; osmotic pressure is the pulling force exerted by proteins. Changes in either the hydrostatic or osmotic pressure in the glomerulus or Bowman\'s capsule will change GFR.)