There are three possible fates for immature B cells with IgM

There are three possible fates for immature B cells with IgM that recognizes self-antigens...

Under what circumstances would a self-reactive cell undergo apoptosis?

Solution

in order to rescue cells from programmed cell death, called apoptosis. It is thought that B cells have undergone receptor editing making it the most common method of removing self reactive B cells. this is preventive process to save cells from autoimmune disease.