Which of the following events is usually associated with a d

Which of the following events is usually associated with a decrease in gene expression in eukaryotes? The methylation of histone tails by histone methyltransferases. The methylation of DNA by methyl transferases. The acetylation of histone tails by histone acetyltransferases. The binding of transcription factors to upstream enhancer elements. The phosphorylation of the carboxyl terminal domain of RNA polymerase II by TFIIH.

Solution

B. The methylation of DNA with DNA methyltransferase.

DNA methylation repress the gene expression. whereas the effect of histone or protein methylation is site dependent means some places it can activate the gene expression and someplaces it can repress the gene expression.

Phosphorylation and acetylation always activate the gene expression.

the binding of transcription factor to upstream enhancer element and the phosphorylation of C-terminal of RNA polymerase will activate the gene expression.