There are three possible fates for immature B cells with IgM

There are three possible fates for immature B cells with IgM that recognizes self-antigens...

Under what circumstances would a self-reactive cell become anergic?

Solution

Self reactive cell activated when cell is encountered by their specific antigen and cell undergoing rewiring of cellular processes. In response of antigen reactive cell become non responsive (anergic)

This helpful in certain condition where requirement to reduce immunity of patient like organ transfer or any other.