Kevin Kellers aunts husband and his girl cousin have died of

Kevin Keller’s aunt’s husband and his girl cousin have died of heart attacks, but his mother, sister, and brother are fine. Lisa Keller’s uncle is fine, but her aunt had multiple miscarriages before she died. Her mother suffered from deep vein thrombosis, and her grandfather died of a heart attack. Recall that Lisa has a brother with hemophilia C and an unaffected sister. Lisa and Kevin Keller are husband and wife.

A) Create a pedigree diagramming these relationships.

B) Who do you think is more likely to carry the Factor V Leiden mutation?

Kevin Keller

Lisa Keller

Both

C) Looking at the Kellers and Morrisons, is it possible that Kevin Keller had an affair with Cynthia Morrison and is Diana Morrison’s biological father? Show work.

D) What do you think happened with the Morrison’s and Keller’s when Olivia and Diana were young?

Lisa Keller Kevin Keller Cynthia Morrison Mr. Morrison O+ B+ Diana Morrison Olivia Keller O- A+

Solution

B). Lisa killer carries the factor V Leiden mutation because her mother suffered from deep vein thrombosis. Since this factor V Leiden mutation is a inherited genetic disorder of blood clotting, this mutation is carried from mother to her child (Lisa).

C). Yes, the diagram is clearly showing that Kevin Keller had an affair with Cynthia morrison and Diana Morrison\'s biological father because Diana Morrison has A+ blood group but none of her parents is having A genotypic allele in their blood group, Whereas it is inherited from Lisa Kellers.