A noncompetitive inhibitor binds to an allosteric site and p

A non-competitive inhibitor binds to an allosteric site and prevents substrate from binidng to the active site. Non-competitive inhibition:

A-cannot be overcome by increasing substrate concentration

B-maintains constant Vmax of a reaction

C-increases Vmax of a reaction

D-is affected by concentrations of substrate

Solution

In Non- competitive inhibition, the inhibitor binds to an allosteric site and prevents subrate from binding. It Km is unchanged, but Vmax is reduced. Non competitive inhibitor binds to the enzyme substrate complex, and hence is not affected by increasing substrate concentration.

The correct sentence for the above question is noncompetitive inhibition cannot be overcome by increasing substrate concentration