What are the factors that underlie the observation that EBV

What are the factors that underlie the observation that EBV infection give rise to so many tumor types?

a. Different virus latency programs combined with the state of B cell differentiation

b. A single virus latency program acting on B cell mutations during maturation

c. Different virus latency programs in B blast cells cause different tumor types

d. A single virus latency program acting on different states of B cell differentiation

Solution

c. Different virus latency programs in B blast cells cause different tumor types

Some of the EBV infected lymphocytes remain in the circulation, the virus remains in a latent state. When activated, each of these cells give rise to a spontaneous outgrowth of EBV transformed, immortalized cell lines.