Graphics Sequence ID Query 213187 Length 4443 Number of Matc

Graphics Sequence ID Query 213187 Length 4443 Number of Matches: 1 V Next Match A Previous Match Range 1: 1 to 4443 Graphics Expect Identities Strand Score Gaps 8205 bits (4443) 0.0 4443/4443(100%) 0/4443 (0%) Plus/Plus Query 1 ATGCAGAGGT CGCCTCTGGAAAA GGCCAGC GTTGTCTCCAAACtttttttCAGCTGGACC 60 Sbjct 1 ATGCAGAGGT CGCCTCTGGAAAA GGCCAGCG TTGTCTCCAAA CTTTTTT TTCAGCTGGACC 60 Query 61 AGACCAATTTTGAGGAAAGGATACAGACAGCGCCTGGAATTGTCAGACATATACCAAATC 120 Sbojct 61 AGACCAATTTTGAGGAAAGGATACAGACAGCGCCTGGAATTGTCAGACATATACCAAATC 120 Query 121 TTGGAAAGAGAATGGGATAGAGAG 180 Sbjct 121 TTGGAAAGAGAATGGGATAGAGAG 180 Query 181 CTGGCTTCAAAGAAAAATCCTAAACTCATTAATGCCCTTCGGCGATGTTTTTTCTGGAGA 240 Sbjct 181 CTGGCTTCAAAAGAAAAATCCTAAACTCATTAATGCCCTTCGGCGATGTTTTTTCTGGAGA 240

Solution

Well the answer depends the difference is called a \"mutation\" usually.

Mutations can be additions or deletions of nucleotides or simply change of nucleotide at a particular location called substitutions.

Now let me explain,

The mutations that will affect the protien most are usually additions or deletions.

because such type of mutations usually lead to frame shift in coding sequence as a result the triplet sequence of all the following codons change, resulting in different poly-peptide chain all together and this type of mutation usually causes loss of function ...

Comming to substitutions ... nucleotide substitutions or SNPs single nucleotide polymorphisms can be synonymous (silent substitutions) or non-synonymous.

If a substitution does not change the amino acid coded by a particular codon then that substitution is conserved and does not affect function of protien and protien formed is fully functional.

If the substitution is non-synonymous which means that a nucleotide substitution changes the amino acid coded by involved codon, then it can have a varied effect on protien formed as it can enhance function , decrease function, make protien non functional etc. depending upon importance of mutated amino acid in the protien .... eg, if the amino acid mutated was involved in active site of protien it can have varied effects similarly we find glutamic acid (GAG) to valine (GTG) mutation in haemoglobin giving people sickle cell anaemia ... and so on.

Hope it helps.... FEEL FREE TO COMMENT AND DISCUSS... I will be glad to help you with question related querries.....

Regards