According to JBS Haldanes theory of aging the increased prev

According to J.B.S. Haldane\'s theory of aging the increased prevalence of Huntington\'s Chorea with increasing age is likely influenced by: (Choose all that apply):

Solution

Answer: 3. a decrease in selective pressure to remove deleterious traits with increasing age.

Reason:

The mutated genes coding for the trinucleotide nitrogen base repeats existing as CAG- polyglutamine as it is due to point mutation in respective genes and finally these mutant genes code for protein \"huntingtin\" with increasing age becomes neurodegenerative disease. According to Haldane theory, as the age is increasing, the \"natural selection cannot remove these mutated deleterious alleles\" due to dominance of inbreeding depression finally fixation of deleterious allele occurs with senescence. These events are leading to a decrease in selective pressure to remove deleterious traits with increasing age