1What is the meaning of the phrase Eukaryotic regulatory pro
1.What is the meaning of the phrase ‘Eukaryotic regulatory proteins are typically modular in nature’?
Solution
Transcription in eukaryotic cells is controlled by proteins that bind to specific regulatory sequences which modulate the activity of RNA polymerase. The domains present in proteins are composed of evolutionary units which either have an independent function or may contribute to working of mutidomain protein. Duplication of domain results in new or modified function. Pol I, Pol II, Pol III are three RNA polymerases present in eukaryotes. Each polymerase has specific activity regulated by independent mechanisms. The modular protein domains helps to independently fold and bind short peptide ligands both in vivo and in vitro which helps significant protein- protein interactions.
