Think about the similarities and differences that benign non

Think about the similarities and differences that benign (non-cancerous) and malignant (cancerous) tumors. Which mutations do both malignant and benign tumors most likely have and what characteristic of the tumor does that mutation cause?

Solution

Similarites

1. Both grow in uncontrolled manner.
2. Both can form tumor even after surgery.
3.Both become dangerous if untreated eg.Begin brain tumor and Lung cancer.
4. Both increases the size of the tumor.

Difference
Benign                                                                 Maligant
1. Growth rate very slow                             Growth rate Fast
2. No metastatis                                       Metastatis - Spread to other part of the body
3. No Angiogenesis                                    Angiogenesis - Forming new blood vessels
4. Treatment easy surgery                          Treatment - Radiation, Chemotherapy etc
5. It is sticky to surface      It dont produce any sticky molecule. So, it float and metastatis occur.

APC gene responsible for both Benign and maligant colon cancer. Polyps Precancerous cells initially evolve inside
of colon wall. After period of time if not treated another mutation happen in ras gene turns into maligant.

Characteristic of tumor

Rapid growth
Density independent growth
No differentiation
No contact inhibition
No apotosis