Describe the cause and result of the first genetic alteratio

Describe the cause and result of the first genetic alteration to occur in a lung cancer patient\'s body.

•Identify the tissue/organ where the first affected cell would have been (if the mutation was inherited then explain which parent the mutation came from).

•What type of gene was affected? Did it have an effect on cellular processes?

Solution

Thanks for the question

The first change to occur in a lung cancer case scenario would be a mutation. This is nothing but a change in the normal genetic expression of the cell. This cell cound be a part of the bronchi (ciliated columnar epithelium) or in the lung parenchyma (non ciliated columnar or squamous epithelium)

The effect a can cer cell has on the surrounding tissues is that

1. abnormal cells are produced

2. They have unrestricted growth

3. They multiply without control

4. There is new blood vessel proliferation to support the nely formed tumor tissue

There are amny causes responsible for the first genetic alteration to occur in alung cancer patients body. These include genes such as

1. chromosome 14q13.3 ammplification which contains NKX@-1 prtooncogene

2. Oncogene FUS

3. Oncogene MYC

4. EGFR gene

5. KRAS gene

Some of the most common carcinogens causing lung cancer are

1. cigarette smoking - cigarettes have more than 20 carcinogens

2. lead

3. arsenic

4. toxic gases

Regards