Consider this strand of mRNA as a template for a normal prot

Consider this strand of mRNA as a template for a normal protein. Use this strand to create a missense mutation. AUGGCUAGGUAUGCCUGA. What environmental factor led to the mutation? Use the strand template to create a sense mutation. AUGGCUAGGUAUGCCUGA. What nucleotide substitution position is more likely or critical for this mutation to occur? What amino acids will likely be introduced by this mutation? What environmental factor led to the mutation?

Solution

mRNA: AUG GCU AGG UAU GCC UGA

Amino acid sequence: Met Ala Arg Tyr Ala STOP

Missense mutation : It is a point mutation resulting in change of single nuceotide base coding for same or another amino acid.

mRNA with mutation : AUG GCU AGA UAU GCC UGA

In the above mutation A to G transition or point mutation. The codons AGG and AGA both code for Arginine. It can be caused either due to UV radiation or chemical agents.

2. mRNA: AUG GCU AGG UAU GCC UGA

Amino acid sequence: Met Ala Arg tyr Ala STOP

Mutation in mRNA: AUG GCU AGG AUA UGC CUG A

Amino acid sequence: Met Ala Arg Ile Cys Leu

The introduction of base \'A\' in the mRNA sequence results altered amino acid sequence producing a functional protein. This is a sense mutation caused due to frame shift mutation and the mutation is caused due to chemical agents or UV radiation.