According to a recent study 1 out of 50000 people will be di

According to a recent study, 1 out of 50,000 people will be diagnosed with cystic fibrosis. Cystic fibrosis can be caused by a mutant form of the CFTR gene (dominant gene symbol is F and mutant is f). MAKE SURE TO USE CHI SQUARE METHOD. (E-O)^2/E

a. Using the rate of incidence above, what is the frequency of carriers of the cystic fibrosis allele for CFTR in the US? (3 pts0 b. In a clinical study, 400 people from the population mentioned in (a) were genotyped for BRCA1 gene. Listed below are the results. Are these results in Hardy- Weinberg equilibrium? Use Chi Square to show whether or not they are. (3 pts) ff of women BRCA1 genotype 390 BB 10 Bb bb

Solution

a). The inheritance pattern of inheritance of cystic fibrosis is autosomal recessive. It is given that the frequency of occurrence in the US population is = 1 in 50, 000

Assuming that the gene coding for cystic fibrosis is f and its dominant wild type allele is F and is exhibits complete dominance,

The frequency of cc in the population is, ff or q2 = 1/50,000

The frequency of q = 0.0044

Assuming that the population is in H-W equilibrium, the frequency of dominant allele F or the frequency of p is = 1- 0.0044 = 0.9956

The frequency of CFTR carriers is = 2pq = 2*0.0044*0.9956 = 0.0087