A 77 year old female with a past history of myocardial infar

A 77 year old female with a past history of myocardial infarction expires while at home alone. Autopsy is performed to confirm cause of death.   A large brain lesion is detected in the left hemisphere frontal lobe. Gross and microscopic evidence suggests a severe hypoxic lesion aged several hours. What did the pathologist find that confirmed this finding?

A. ghost cells retaining the outline of the tissue

B. Acute meningitis with hyperplasia of neuroglial cells

C. loss of neurons and neuroglial cells with complete loss/dissolution of tissue architecture

D. Dysplasia indicating cancerous transformation of neuronal cells

E. Infection with clostridium perfringrens and release of noxious gas

Solution

E. Infection with  clostridium perfringrens and release of noxious gas

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A large brain lesion is detected in the left hemisphere frontal lobe.

Clostridium perfringens is the most widely recognized bacterial specialist for gas gangrene, which is corruption, rot of tissues, and gas generation.

It is brought about essentially by Clostridium perfringens alpha poison.

The gasses frame rises in muscle (crepitus) and the trademark smell in breaking down tissue. After fast and damaging neighborhood spread .

systemic spread of microorganisms and bacterial poisons may bring about death.

C. perfringens develops promptly on blood agar plate in anaerobic conditions, and regularly delivers a twofold zone of beta hemolysis.