Deponit is a nitroglycerin transdermal delivery system for t

Deponit is a nitroglycerin transdermal delivery system for the prevention of angina pectoris. The in vivo release rate of the 16 cm^2 patch is 0.2 mg h^-1. The reported volume of distribution is 3 L kg^-1 BW^-1 and the observed clearance rate is 1 L kg^-1 BW^-1 min^-1. What is the steady state nitroglycerine concentration (nanograms per milliliter) in a 70 kg human? What is the elimination rate constant in 1 min^-1? What is the half-life of nitroglycerine in minutes?

Solution

the steady sate nitroglycerine concentration is 50 mg in 250 ml D5W

The elimination rate constant is the amount of drug elimated per unit time and is abbreviated as Ke

Clearance rate is 103 ml/min.

Nitroglyceerine plasma concentration decreases rapildly with a mean elimination half life of 2-3 minutes.Clearance 13.6 L/m greatly exceeds hepatic blood flow.Metabolism is the primary route of drug elimination.