explain how native disorder in proteins affects the overall

explain how native disorder in proteins affects the overall free energy of binding. it is helpful to think of this as a schulz diagram

The Schulz diagram flexible maiko ies Do NOT Both solid for spooit city Resulting AG gned paper (Dunker) Specifi excess strengt What is specific

Solution

Schulz diagram: It is analysis of free energy changes from disorder to order

In schulz diagram a represents binding partner shows flexibility in solution.

                             b represents on binding, the flexible partner solidifies

According to diagram step 1 indicates free energy change as the disorder is lost upon complex formation due to contains enthalpic and entropy contributions.

Step 2 : indicates free energy due to all the contact between partner

schulz diagrams for rigid partner : It is contact free energy between a rigid partner can be altered by changing the extent of the contact

schulz diagrms for variable contact surfaces : the contact surface of rigid partner can change and the flexible partner can evolve to conform to the altered surface , leading to mutiple specificities .