If TP53 retro genes do not produce functional proteins how m

Solution

Cancer cells are neoplastic cells and they have a property of uncontrollable division to form benign and become malignant when they migrate from region to another region. They have a property of angiogenesis means cancer cells have ability to obtain nutrients by synthesizing new blood vessels to their site of origin. Normal cells deficient of these properties of uncontrollable division. Tumor cells have “no active tumor suppressor p53 gene” but active p53 gene existing in normal cells. Telomerase activity is deficient in tumor cells but in normal cells possess telomerase activity.

If TP53 retro genes do not produce functional proteins, TP53 is the protein isoforms responsible for controlling the changes in genome of cells due to any mutational changes and trigger cell cycle arrest by inhibiting the G1/S cell cycle interphase regulation point (so that TP53 genes still be protective) as soon as DNA damage detected. Finally, it promotes elimination of damaged cells by triggering apoptosis of cancer cells.