Homework SourseA how do miRNAs regulate gene expression Is this regulation
A) how do miRNAs regulate gene expression ? Is this regulation positive or negative ?
B) consider miRNA target sites, how do these compare to transcription factor binding sites ? Imagine that both miRNA target sites and transcription factor binding sites were dispersed randomly in the genome? Which would be likely to appear more frequently ?
A) how do miRNAs regulate gene expression ? Is this regulation positive or negative ?
B) consider miRNA target sites, how do these compare to transcription factor binding sites ? Imagine that both miRNA target sites and transcription factor binding sites were dispersed randomly in the genome? Which would be likely to appear more frequently ?
B) consider miRNA target sites, how do these compare to transcription factor binding sites ? Imagine that both miRNA target sites and transcription factor binding sites were dispersed randomly in the genome? Which would be likely to appear more frequently ?
Solution
(A)
miRNAs (microRNAs) are short non-coding RNAs that regulate gene expression post-transcriptionally. They bind to target sequences in mRNAs, typically resulting in repressed gene expression. Therefore they negatively regulate gene expression. They generally bind to the 3\' untranslated region of their target mRNAs and repress protein production by destabilizing the mRNA and translational silencing.
