Considering the types of side chains on amino acids and thei

Considering the types of side chains on amino acids and their relationship to protein structure, where are the amino acids with hydrophobic side chains most likely to be located?

Solution

It depends on the environment in which protein is present.

For example, in transmembrane proteins hydrophobic amino acids are in contact with the hydrophobic tail of the plasma membrane via hydrophobic interaction whereas in case of an enzyme or cytoplasmic proteins or secretory proteins hydrophobic side chains are buried inside the protein