What is the relationship between mRNA stability and mRNA con

What is the relationship between mRNA stability and mRNA concentrations? What factors affect mRNA stability?

Solution

According to various researches done it has been established that the most concentrated RNAs are the most unstable ones which means that concentration and lifespan of RNA is inversely correlated.

Factors affecting mRNA stability :

1. 3\' Non translated region of the RNA gives it stability.

2. 5\' cap gives it stability.

3. 3\' tail also provides an stablr mRNA.

4. Poly A tail helps mRNA in export and translation and thus protects mRNA from degradation.